Platinum(IV) Carboxylate Prodrug Complexes as Versatile Platforms for Targeted Chemotherapy

Platinum(IV) Carboxylate Prodrug Complexes as Versatile Platforms for Targeted Chemotherapy

Blog Article

Kinetically-inert Pt(IV) carboxylate complexes have emerged in recent years as candidates for the development of next-generation platinum anticancer drugs.Being native prodrugs Water Conditioners of clinically-important Pt(II) chemotherapeutic agents, the Pt(IV) scaffold can be exploited to incorporate additional functionalities while keeping the Pt(II) pharmacophore intact.This mini-review examines recent work performed to illuminate APPLE PECTIN the mechanism of Pt(IV) prodrug activation and their use as versatile platforms for targeted chemotherapy.